Except like FunkyGreenJersualem pointed out, it already has been written about. Steven Shaviro wrote a whole book about the series and how it relates to postmodernism. The Amazon link:

http://www.amazon.com/Doom-Patrols-Theoretical-Postmodernism-Serpents/dp/1852424303/ref=sr_1_1?ie=UTF8&s=books&qid=1215726777&sr=8-1

Tim Callahan's book about Grant Morrison's early career also covers the series in detail:

http://www.amazon.com/Grant-Morrison-Early-Timothy-Callahan/dp/0615140874/ref=sr_1_1?ie=UTF8&s=books&qid=1215726826&sr=1-1

In the history of Comics, Sandman will be written about…Morrison’s Doom Patrol might not even be a foot note.

Doom Patrol's already been written about in books.

And honestly, shouldn't every issue of this be Sandman if we're going to talk about which comics 'will be written about'?

Star Trek #19 (First DC series) featured special stunt guest writer Walter Koenig.

Sorry, buddy, but as much as I too love Quasar, i think that Ditko beat Gru to the 'superhero just flat out tells the love interest to avoid a misunderstanding' with Blue Beetle #2 back in the 60s.

Re: Doom Patrol vs. Sandman, I can't really vote on this one, as I've never read that far into Sandman. DP #19 was the first 19 I thought of, but again, I hadn't read Sandman past the first TPB. (I'll get around to it eventually, dammit.)

Too bad we're not going to #123; that's one everyone could agree on!

Alas, no love for Mimic and his debut in X-men 19.

But you're right one would have to stretch to get those last few, less key issues of a Top Fifty. Still... makes for some interesting discussion on some noteworthy comics.

Not only did Dazzler #19 feature Absorbing Man AND black Bolt, but it was titled-- wait for it -- "Creel...and inhuman treatment!"

Ultimately, as strong as the Gaiman issue is (and it is certainly better than Doom Patrol #19), I do not think it has the same notableness of Morrison’s first issue of Doom Patrol. I wasn’t even sure which issue of Sandman HAD the Midsummer’s Night Dream story in it!

This is kind of what I was getting at before, Brian. If the criterion is the NUMBER itself of the significant/memorable comic, it's gota be Sandman. If it's the NUMBER YOU THINK PEOPLE WILL REMEMBER, I doubt you'll make fifty and there's going to be quite a few where you'll have to reach for it. This seems pretty clearly to me to be one of them.

For: "I wasn’t even sure which issue of Sandman HAD the Midsummer’s Night Dream story in it!"

I think the same could be said if you asked around "What issue did Morrison begin on Doom Patrol".

Sandman 19 is a major book in comics and out. In the history of Comics, Sandman will be written about...Morrison's Doom Patrol might not even be a foot note.

Um, Brian, you are aware that they actually changed the rules of the World Fantasy Awards after this issue won to prevent graphic literature to ever be nominated again. At the time its winning (and the changing of the rules around it) was incredibly controversial.

I'd hope so, because it was in the piece.

but Neil Gaiman’s amazing issue of The Sandman deserves serious recognition (which it got - by winning a World Fantasy Award, an occurrence so dramatic that they changed the rules afterwards so that comic books were ineligible!)!!